HP Lovecraft died before injections of penicillin were freely on offer but I highly doubt he would have accepted any if they had been available.
His particular set of monsters and horrors were slippery slimy moldy thingies and the thought to him of someone voluntarily polluting their sacred human temple with the pee and poop of such terrors was literally beyond the ken.
Popular culture hasn't really moved on from Lovecraft's deepest fears -- it still sees giant gooey slimy dissolving fluid lifeforms as the most terrifying of the 'monstrous made visible'.
But once outside the movieplex, we are quite willing to have white crystal-pure 'beta lactam' antibiotics from huge factories put into our 21st century human temples - despite half-knowing that the pure white powder actually originates as the time-honored waste excretions of Lovecraft's still terrifying green slime.
Penicillin (today's all-white version anyway) seems safely far far away from the moldy smelling blue-green slime that we , doctors and patients alike, still fear is rotting out our teenager's basement apartment and making our worksite "toxic" and "sick".
Because consistency is truly 'the hobgoblin of little minds' and we are broad minded adults here , are we not ?